Convergent synthesis of the EFGH ring fragment of ciguatoxin CTX3C

被引：44

作者：

Imai, H

Uehara, H

Inoue, M

Oguri, H

Oishi, T

Hirama, M ^{[1
]}

机构：

[1] Tohoku Univ, Dept Chem, Grad Sch Sci, Sendai, Miyagi 9808578, Japan

[2] Japan Sci & Technol Corp, CREST, Sendai, Miyagi 9808578, Japan

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 35期

关键词：

ring-closing metathesis; acetal cleavage; radical reaction; ciguatoxin; polyethers; stereocontrolled synthesis;

D O I：

10.1016/S0040-4039(01)01219-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereoselective synthesis of the EFGH ring fragment of ciguatoxin CTX3C has been achieved through: (i) selective cleavage of a dioxepane acetal C O bond; (ii) radical cyclization to form the oxepane G ring; and (iii) chemoselective ring-closing metathesis of a triene yielding the hexahydrooxonin F ring. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：6219 / 6222

页数：4

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