Antihypertensive effect of total flavones extracted from seed residues of Hippophae rhamnoides L. in sucrose-fed rats

被引：114

作者：

Pang, Xiufeng ^{[1
]}

Zhao, Jingjing ^{[1
]}

Zhang, Wen ^{[1
]}

Zhuang, Xiuyuan ^{[1
]}

Wang, Jiesi ^{[1
]}

Xu, Ruiqi ^{[1
,3
]}

Xu, Ziliang ^{[2
]}

Qu, Weijing ^{[1
]}

机构：

[1] E China Normal Univ, Sch Life Sci, Shanghai 200062, Peoples R China

[2] Zhejiang Hosp Tradit Chinese Med, Hangzhou 310006, Peoples R China

[3] Univ Copenhagen, Fac Sci, DK-1350 Copenhagen, Denmark

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2008年 / 117卷 / 02期

关键词：

Hippophae rhamnoides; flavones; hypertension; hyperinsulinemia; angiotensin II;

D O I：

10.1016/j.jep.2008.02.002

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The study was designed to investigate the antihypertensive effect of total flavones extracted from seed residues of Hippophae rhamnoides L. (TFH-SR) and its underlying mechanism in chronic sucrose-fed rats by evaluating its ability to regulate insulin and angiotensin II levels. Feeding of high-sucrose diet (HS: 77% of kcal from carbohydrate, 16% from protein and 6% from lipid, respectively) for 6 weeks resulted in significant rise in systolic blood pressure (SBP) by 25.60%, plasma insulin by 114.24%, triglycerides by 85.14% and activated angiotensin II contents in heart and kidney. However, TFH-SR treatment significantly suppressed the elevated hypertension, hyperinsulinemia and dyshpidemia. Furthermore, TFH-SR (especially at the dose of 150 mg/kg/day) increased the circulatory blood angiotensin II level as effective as angiotensin II receptor blocker. These results indicated that TFH-SR exerted its antihypertensive effects at least in part by improving insulin sensitivity and blocking angiotensin II signal pathway. Findings of the present study suggested that TFH-SR might prove to be of potential use in the management of hyperinsulinemia in non-diabetic state with cardiovascular diseases. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：325 / 331

页数：7

共 53 条

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