New chemotypes for cathepsin K inhibitors

被引：17

作者：

Teno, Naoki ^{[1
]}

Irie, Osamu ^{[1
]}

Miyake, Takahiro ^{[1
]}

Gohda, Keigo ^{[1
]}

Horiuchi, Miyuki ^{[1
]}

Tada, Sachiyo ^{[1
]}

Nonomura, Kazuhiko ^{[1
]}

Kometani, Motohiko ^{[1
]}

Iwasaki, Genji ^{[1
]}

Betschart, Claudia ^{[1
]}

机构：

[1] Novartis Inst BioMed Res, Tsukuba, Ibaraki 3002611, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 08期

关键词：

cathepsin K; non-peptidic inhibitors; new chemotype; cyano pryrimidine acetylene; cyano pyrimidine t-amine;

D O I：

10.1016/j.bmcl.2008.03.036

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cyano pyrimidine acetylene and cyano pyrimidine t-amine, which belong to a new chemical class, were prepared and tested for inhibitory activities against cathepsin K and the highly homologous cathepsins L and S. The use of novel chemotypes in the development of cathepsin K inhibitors has been demonstrated by derivatives of compounds 1 and 8. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2599 / 2603

页数：5

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