Hypoglycemic effect of S(-)-hydroxyhexamide, a major metabolite of acetohexamide, and its enantiomer R(+)-hydroxyhexamide

被引:3
作者
Imamura, Y
Sanai, K
Seri, K
Akita, H
机构
[1] Kumamoto Univ, Fac Pharmaceut Sci, Kumamoto 8620973, Japan
[2] Godo Shusei Co, Cent Res Lab, Chiba 2710064, Japan
[3] Toho Univ, Sch Pharmaceut Sci, Chiba 2748510, Japan
关键词
S(-)-hydroxyhexamide; R(+)-hydroxyhexamide; hypoglycemic effect; insulin secretion;
D O I
10.1016/S0024-3205(01)01284-X
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
A short-lasting hypoglycemic effect was observed when S(-)-hydroxyhexamide (S-HH), a major metabolite of acetohexarnide, and its enantiomer R(+)-hydroxyhexamide (R-HH), were administered orally to rats. Since the reductive metabolism of acetohexamide is known to be reversible in rats, oral administration of R-HH may exhibit the hypoglycemic effect through the generation of acetohexamide. However, oral administration of R-HH to rabbits, in spite of their inability to oxidize R-HH to acetohexamide, caused a significant decrease and increase, respectively, of plasma glucose and insulin levels. Furthermore, both S-HH and R-HH were found to stimulate the secretion of insulin from hamster HIT T15 cells (pancreatic beta -cells). These results provide further evidence that both R-HH and S-HH exhibit a significant hypoglycemic effect. (C) 2001 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:1947 / 1955
页数:9
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