Targeting of the virulence factor acetohydroxyacid synthase by sulfonylureas results in inhibition of intramacrophagic multiplication of Brucella suis

被引：25

作者：

Boigegrain, RA ^{[1
]}

Liautard, JP ^{[1
]}

Köhler, S ^{[1
]}

机构：

[1] Univ Montpellier 2, INSERM, U431, F-34095 Montpellier, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 09期

关键词：

D O I：

10.1128/AAC.49.9.3922-3925.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

The acetohydroxyacid synthase (ARAS) of Brucella suis can be effectively targeted by the sulfonylureas chlorimuron ethyl and metsulfuron methyl. Growth in minimal medium was inhibited, and multiplication in human macrophages was totally abolished with 100 mu M of sulfonylureas. Metsulfuron methyl-resistant mutants showed reduced viability in macrophages and reduced AHAS activity.

引用

页码：3922 / 3925

页数：4

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