Reduced decrease of peripheral vascular resistance during exercise in young type I diabetic patients

被引:9
作者
Matthys, D
Craen, M
DeWolf, D
VandeWalle, J
Verhaaren, H
机构
[1] Department of Pediatrics, University Hospital, Gent
[2] Kliniek voor Kinderziekten C. Hooft, Universitair Ziekenhuis Gent, 9000 Gent
关键词
D O I
10.2337/diacare.19.11.1286
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE - In normal subjects, peripheral vascular resistance decreases during dynamic exercise. We studied blood pressure and peripheral vascular resistance responses to dynamic exercise in young normotensive type I diabetic patients. RESEARCH DESIGN AND METHODS - Thirty adolescent diabetic patients (9-19 years of age) underwent a maximal exercise test on a cycle ergometer. In a subset of 14 patients, cardiac output was measured by a CO2 rebreathing method and peripheral vascular resistance was calculated Twenty-four normal individuals, age and sex matched, served as control subjects. RESULTS - Diastolic blood pressure was significantly higher in diabetic patients at intermediate workload (77 +/- 2 vs. 71 +/- 1 mmHg) and peak exercise (86 +/- 2 vs. 73 +/- 2 mmHg). Peripheral vascular resistance was significantly higher in diabetic patients at intermediate workload (17.0 +/- 1.1 vs. 12.6 +/- 0.5 mmHg . l(-1) . min(-1) . m(-2)) and peak exercise (16.3 +/- 1.3 vs. 11.4 +/- 0.5 mmHg . l(-1) . min(-1) . m(-2)). There were no significant correlations with the patient's age, diabetes duration, or diabetes control. CONCLUSIONS - We observed the decrease of vasodilator response during dynamic exercise in normotensive young type I diabetic patients.
引用
收藏
页码:1286 / 1288
页数:3
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