Common genetic changes between endometriosis and ovarian cancer

被引：74

作者：

Obata, K ^{[1
]}

Hoshiai, H ^{[1
]}

机构：

[1] Kinki Univ, Sch Med, Dept Obstet & Gynecol, Osakasayama, Osaka 5898511, Japan

来源：

GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 2000年 / 50卷

关键词：

malignant transformation; atypical endometriosis; LOH; PTEN mutation;

D O I：

10.1159/000052877

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

We analyzed 81 ovarian cancers for loss of heterozygosity (LOH) on 10q23 and for mutations in PTEN. LOH was common among the endometrioid (43%) and serous (28%) cancers, but was infrequent among the other histological subtypes. Somatic PTEN mutations were detected in seven (21%) endometrioid cancers and the mutation in all informative cases was accompanied by loss of the wild-type allele. One mucinous cancer without 10q23 LOH was shown to harbor two somatic PTEN mutations. Frequent LOH was observed on chromosome 6q (60.0%) and chromosome 10q (40.0%) in ovarian atypical endometriosis, but no PTEN mutations were observed. These findings support the hypothesis that endometrioid and clear cell ovarian carcinomas may arise through malignant transformation of endometriotic lesions. Copyright (C) 2000 S. Karger AG, Basel.

引用

页码：39 / 42

页数：4

共 19 条

[1]

CZERNOBILSKY B, 1979, OBSTET GYNECOL, V53, P318

[2] Histologic transformation of benign endometriosis to early epithelial ovarian cancer [J].

DelaCuesta, RS ;

Eichhorn, JH ;

Rice, LW ;

Fuller, AF ;

Nikrui, N ;

Goff, BA .

GYNECOLOGIC ONCOLOGY, 1996, 60 (02) :238-244

[3] Ovarian atypical endometriosis: Its close association with malignant epithelial tumours [J].

Fukunaga, M ;

Nomura, K ;

Ishikawa, E ;

Ushigome, S .

HISTOPATHOLOGY, 1997, 30 (03) :249-255

[4]

Jiang XX, 1998, CANCER RES, V58, P1707

[5]

Jiang XX, 1996, CANCER RES, V56, P3534

[6] PTEN1 is frequently mutated in primary endometrial carcinomas [J].

Kong, DH ;

Suzuki, A ;

Zou, TT ;

Sakurada, A ;

Kemp, LW ;

Wakatsuki, S ;

Yokoyama, T ;

Yamakawa, H ;

Furukawa, T ;

Sato, M ;

Ohuchi, N ;

Sato, S ;

Yin, J ;

Wang, SN ;

Abraham, JM ;

Souza, RF ;

Smolinski, KN ;

Meltzer, SJ ;

Horii, A .

NATURE GENETICS, 1997, 17 (02) :143-144

[7] OVARIAN-TUMORS ASSOCIATED WITH ATYPICAL ENDOMETRIOSIS [J].

LAGRENADE, A ;

SILVERBERG, SG .

HUMAN PATHOLOGY, 1988, 19 (09) :1080-1084

[8]

Li DM, 1997, CANCER RES, V57, P2124

[9] PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer [J].

Li, J ;

Yen, C ;

Liaw, D ;

Podsypanina, K ;

Bose, S ;

Wang, SI ;

Puc, J ;

Miliaresis, C ;

Rodgers, L ;

McCombie, R ;

Bigner, SH ;

Giovanella, BC ;

Ittmann, M ;

Tycko, B ;

Hibshoosh, H ;

Wigler, MH ;

Parsons, R .

SCIENCE, 1997, 275 (5308) :1943-1947

[10]

MACMEEKIN DS, 1995, GYNECOL ONCOL, V59, P81

← 1 2 →