Severe acute respiratory syndrome coronavirus 3a protein is a viral structural protein

被引:97
作者
Ito, N
Mossel, EC
Narayanan, K
Popov, VL
Huang, C
Inoue, T
Peters, CJ
Makino, S [1 ]
机构
[1] Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA
[2] Univ Texas, Med Branch, Dept Pathol, Galveston, TX 77555 USA
[3] Gifu Univ, Fac Appl Biol Sci, Div Vet Med, Lab Zoonot Dis, Gifu, Japan
关键词
D O I
10.1128/JVI.79.5.3182-3186.2005
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The present study showed the association of a severe acute respiratory syndrome coronavirus (SCoV) accessory protein, 3a, with plasma membrane and intracellular SCoV particles in infected cells. 3a protein appeared to undergo posttranslational modifications in infected cells and was incorporated into SCoV particles, establishing that 3a protein was a SCoV structural protein.
引用
收藏
页码:3182 / 3186
页数:5
相关论文
共 33 条
  • [1] THE CLONING AND SEQUENCING OF THE VIRION PROTEIN GENES FROM A BRITISH ISOLATE OF PORCINE RESPIRATORY CORONAVIRUS - COMPARISON WITH TRANSMISSIBLE GASTROENTERITIS VIRUS GENES
    BRITTON, P
    MAWDITT, KL
    PAGE, KW
    [J]. VIRUS RESEARCH, 1991, 21 (03) : 181 - 198
  • [2] CLONING AND SEQUENCING OF A 8.4-KB REGION FROM THE 3'-END OF A TAIWANESE VIRULENT ISOLATE OF THE CORONAVIRUS TRANSMISSIBLE GASTROENTERITIS VIRUS
    CHEN, CM
    CAVANAGH, D
    BRITTON, P
    [J]. VIRUS RESEARCH, 1995, 38 (01) : 83 - 89
  • [3] The group-specific murine coronavirus genes are not essential, but their deletion, by reverse genetics, is attenuating in the natural host
    de Haan, CAM
    Masters, PS
    Shen, XL
    Weiss, S
    Rottier, PJM
    [J]. VIROLOGY, 2002, 296 (01) : 177 - 189
  • [4] Mapping of the coronavirus membrane protein domains involved in interaction with the spike protein
    de Haan, CAM
    Smeets, M
    Vernooij, F
    Vennema, H
    Rottier, PJM
    [J]. JOURNAL OF VIROLOGY, 1999, 73 (09) : 7441 - 7452
  • [5] Identification of a novel coronavirus in patients with severe acute respiratory syndrome
    Drosten, C
    Günther, S
    Preiser, W
    van der Werf, S
    Brodt, HR
    Becker, S
    Rabenau, H
    Panning, M
    Kolesnikova, L
    Fouchier, RAM
    Berger, A
    Burguière, AM
    Cinatl, J
    Eickmann, M
    Escriou, N
    Grywna, K
    Kramme, S
    Manuguerra, JC
    Müller, S
    Rickerts, V
    Stürmer, M
    Vieth, S
    Klenk, HD
    Osterhaus, ADME
    Schmitz, H
    Doerr, HW
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (20) : 1967 - 1976
  • [6] The viral nucleocapsid protein of transmissible gastroenteritis coronavirus (TGEV) is cleaved by caspase-6 and-7 during TGEV-induced apoptosis
    Eléouët, JF
    Slee, EA
    Saurini, F
    Castagné, N
    Poncet, D
    Garrido, C
    Solary, E
    Martin, SJ
    [J]. JOURNAL OF VIROLOGY, 2000, 74 (09) : 3975 - 3983
  • [7] The membrane M protein carboxy terminus binds to transmissible gastroenteritis coronavirus core and contributes to core stability
    Escors, D
    Ortego, J
    Laude, H
    Enjuanes, L
    [J]. JOURNAL OF VIROLOGY, 2001, 75 (03) : 1312 - 1324
  • [8] Immunopurification applied to the study of virus protein composition and encapsidation
    Escors, D
    Capiscol, C
    Enjuanes, L
    [J]. JOURNAL OF VIROLOGICAL METHODS, 2004, 119 (02) : 57 - 64
  • [9] The internal open reading frame within the nucleocapsid gene of mouse hepatitis virus encodes a structural protein that is not essential for viral replication
    Fischer, F
    Peng, D
    Hingley, ST
    Weiss, SR
    Masters, PS
    [J]. JOURNAL OF VIROLOGY, 1997, 71 (02) : 996 - 1003
  • [10] Assembled coronavirus from complementation of two defective interfering RNAs
    Kim, KMH
    Narayanan, K
    Makino, S
    [J]. JOURNAL OF VIROLOGY, 1997, 71 (05) : 3922 - 3931