Roles of cysteine proteinases of trypanosomes and Leishmania in host-parasite interactions

被引：134

作者：

Mottram, JC ^{[1
]}

Brooks, DR

Coombs, GH

机构：

[1] Univ Glasgow, Anderson Coll, Wellcome Unit Mol Parasitol, Glasgow G11 6NU, Lanark, Scotland

[2] Univ Glasgow, Inst Biomed & Life Sci, Div Infect & Immun, Glasgow G12 8QQ, Lanark, Scotland

来源：

CURRENT OPINION IN MICROBIOLOGY | 1998年 / 1卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S1369-5274(98)80065-9

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Trypanosomes and Leishmania contain an abundance of stage-regulated cysteine proteinases encoded by several gene families. Analysis of parasites rendered defective in cysteine proteinase function, either through genetic manipulation or through the use of specific inhibitors, has revealed roles for the enzymes in parasite virulence, in modulation of the host's immune response and in parasite differentiation.

引用

页码：455 / 460

页数：6

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