Intracellular delivery of nanocarriers for cancer therapy

被引:8
作者
Har-el, Yah-el
Kato, Yoshinori
机构
[1] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Div MR Res, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Div Nucl Med, Baltimore, MD 21205 USA
关键词
intracellular delivery; cancer therapy; liposomes; polymeric carriers; nanoparticles; mechanisms;
D O I
10.2174/157341307782418612
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Drug delivery systems largely contribute to cancer therapy in terms of tumor targeting and controlled release of cargo molecules. While targeting of tumor "tissue" has been achieved us in g nanocarriers, delivery of cargo molecules into tumor cell is still challenging. Intracellular delivery of nanocarriers is an essential process to overcome multi-drug resistance and for the delivery of cargo molecules for both therapy and vaccine applications. Nanocarriers may gain access to the interior of target cells either non-specifically, as in adsorptive endocytosis, or specifically, as in receptor-mediated endocytosis. Once internalized, they must subsequently break free of their endosomal compartments in order to deliver their cargo into either the cytosol or nucleus. If the nucleus is the target, as in DNA delivery, the nanocarrier must then traffick to the perinuclear region and deliver the cargo into the nucleus, either by physically transporting DNA through the nuclear pore complex (NPC), or by releasing DNA at the door of the NPC, allowing free DNA to gain access. This review article includes both principles and mechanisms of intracellular delivery of nanocarriers, and gives a few examples of their application.
引用
收藏
页码:329 / 338
页数:10
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