Health-Related Quality of Life Among Patients with Postmenopausal Osteoporosis Treated with Weekly and Monthly Bisphosphonates

被引：12

作者：

Kastelan, Darko ^{[1
]}

Vlak, Tonko ^{[2
]}

Lozo, Petar ^{[3
]}

Gradiser, Marina ^{[4
]}

Mijic, Sime ^{[5
]}

Nikolic, Tatjana ^{[6
]}

Miskic, Blazenka ^{[7
]}

Car, Dolores ^{[6
]}

Tajsic, Gordana ^{[6
]}

Dusek, Tina ^{[1
]}

Jajic, Zrinka ^{[8
]}

Grubisic, Frane ^{[8
]}

Poljicanin, Tamara ^{[9
]}

Bakula, Miro ^{[10
]}

Dzubur, Fedja ^{[1
]}

Strizak-Ujevic, Matilda ^{[11
]}

Kadojic, Mira ^{[12
]}

Radman, Maja ^{[13
]}

Vugrinec, Maja ^{[14
]}

Kuster, Zeljka ^{[14
]}

Pekez, Marijeta ^{[14
]}

Radovic, Endi ^{[15
]}

Labar, Ljubica ^{[16
]}

Crncevic-Orlic, Zeljka ^{[17
]}

Korsic, Mirko ^{[1
]}

机构：

[1] Univ Hosp Zagreb, Dept Endocrinol, Zagreb 10000, Croatia

[2] Univ Hosp Split, Dept Rehabil Med & Rheumatol, Split, Croatia

[3] Outpatient Clin Gynaecol Lozo, Zadar, Croatia

[4] Cty Hosp Cakovec, Dept Internal Med, Cakovec, Croatia

[5] Hlth Med Ctr Phys Med & Rehabil, Jastrebarsko, Croatia

[6] Univ Clin Traumatol, Zagreb, Croatia

[7] Dr Josip Bencevic Gen Hosp, Dept Internal Med, Slavonski Brod, Croatia

[8] Univ Hosp Sestre Milosrdnice, Dept Rheumatol Phys Med & Rehabil, Zagreb, Croatia

[9] Vuk Vrhovac Univ Clin Diabet Endocrinol & Metab D, Zagreb, Croatia

[10] Gen Hosp Sv Duh, Dept Endocrinol Diabet & Metab Disorders, Zagreb, Croatia

[11] Gen Hosp Sibenik, Shibenik, Croatia

[12] Univ Hosp Osijek, Dept Phys Med & Rehabil, Osijek, Croatia

[13] Univ Hosp Split, Dept Diabet Endocrinol & Metab, Split, Croatia

[14] Univ Zagreb, Sch Med, Zagreb 41001, Croatia

[15] Univ Hosp Rijeka, Dept Phys & Rehabil Med, Rijeka, Croatia

[16] Special Hosp Orthopaed, Biograd, Croatia

[17] Univ Hosp Rijeka, Dept Endocrinol, Rijeka, Croatia

来源：

ENDOCRINE RESEARCH | 2010年 / 35卷 / 04期

关键词：

Bisphosphonates; Osteoporosis; Quality of life; EQ-5D; OPTQoL; MONTHLY ORAL IBANDRONATE; ONCE-MONTHLY IBANDRONATE; BONE-MINERAL DENSITY; VERTEBRAL FRACTURES; WEEKLY ALENDRONATE; OPEN-LABEL; WOMEN; RISEDRONATE; THERAPY; TRIAL;

D O I：

10.3109/07435800.2010.505218

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Objective. The present study was designed to assess the effect of monthly ibandronate on health-related quality of life (HR-QoL) in patients with postmenopausal osteoporosis previously treated with weekly bisphosphonates. Methods. HR-QoL was assessed by Euroqol (EQ-5D) and Osteoporosis Targeted Quality of Life (OPTQoL) questionnaires. Results. The EQ-5D questionnaire showed significant improvement associated with ibandronate treatment, occurring in mobility (p < 0.01), usual activity (p < 0.01), pain/discomfort (p < 0.05), and anxiety/depression (p < 0.05). In addition, ibandronate treatment considerably improved patients' perceived health on a visual analog scale (p < 0.001). For the OPTQoL questionnaire, patients reported less physical difficulty (p < 0.001), fewer adaptations in their lives (p < 0.001), and less fear (p < 0.001) with ibandronate than with weekly bisphosphonates. Conclusion. The study demonstrated that patients who were transferred from weekly bisphosphonates to a monthly ibandronate experienced improved HR-QoL.</.

引用

页码：165 / 173

页数：9

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