The many faces of Src: multiple functions of a prototypical tyrosine kinase

被引：124

作者：

Schwartzberg, PL ^{[1
]}

机构：

[1] Natl Human Genome Res Inst, Lab Genet Dis Res, NIH, Bethesda, MD 20892 USA

来源：

ONCOGENE | 1998年 / 17卷 / 11期

关键词：

Src; tyrosine kinase; PDGF-R; integrin;

D O I：

10.1038/sj.onc.1202176

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

c-src was first isolated as the normal cellular homologue of v-src, the transforming gene of Rous Sarcoma virus (Stehelin et al., 1976). As the first proto-oncogene described and one of the first molecules demonstrated to have tyrosine kinase activity, Src has provided a prototype for understanding signal transduction involving tyrosine phosphorylation. Comparison between c-src and activated or transforming mutants of Src including v-src, combined with recent data on the structure of Src family kinases has provided new insight into their regulation. In this review, I will discuss the function of the various domains of Src in light of these mutational and structural studies.

引用

页码：1463 / 1468

页数：6

共 65 条

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