Thermal studies of pharmaceutical clay systems .2. Sepiolite-based systems

Pharmaceutical-clay systems, used as solar radiation shields, obtained by interaction of natural sepiolite and several pharmaceuticals using two methods of preparation (melting the drug onto the clay or by intimate mixing and grinding of both), have been studied. The shielding ability against solar radiation is improved by using these preparation methods. Differential thermal analysis and thermogravimetric analysis confirm displacement of water molecules adsorbed onto the clay surface by the pharmaceutical molecules. The grinding method seems to facilitate adsorption and dispersion of the drug onto the clay surface.