Molecular pathogenesis of chronic lymphocytic leukemia: factors and signaling pathways regulating cell growth and survival

被引：68

作者：

Meinhardt, G ^{[1
]}

Wendtner, CM ^{[1
]}

Hallek, M ^{[1
]}

机构：

[1] Univ Munich, Klinikum Innenstadt, Med Klin, D-80336 Munich, Germany

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 1999年 / 77卷 / 02期

关键词：

D O I：

10.1007/s001090050351

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Chronic lymphocytic leukemia is a malignant disease characterized by clonal expansion of relatively mature B-lymphocytes with a high percentage of cells arrested in the nonproliferative G0/G1 cell cycle phase. Possibly reflecting the clinical heterogeneity observed in patients, various signaling pathways may become affected during the initiation and course of this disease. This review discusses frequent alterations concerning proliferative, differentiation-inducing, and apoptotic pathways elucidated in the recent years that have improved our understanding of this disease.

引用

页码：282 / 293

页数：12

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