Cytoplasmic HuR expression correlates with epithelial cancer cell but not with stromal cell cyclooxygenase-2 expression in mucinous ovarian carcinoma

被引：28

作者：

Erkinheimo, TL

Sivula, A

Lassus, H

Heinonen, M

Furneaux, H

Haglund, C

Butzow, R

Ristimäki, A

机构：

[1] Univ Helsinki, Dept Obstet & Gynecol, Helsinki, Finland

[2] Univ Helsinki, Dept Pathol, Helsinki, Finland

[3] Univ Helsinki, Dept Surg, Helsinki, Finland

[4] Univ Helsinki, Biomedicum Helsinki, Mol & Canc Biol Res Program, Helsinki, Finland

[5] Univ Helsinki, Cent Hosp, Helsinki, Finland

[6] Univ Connecticut, Ctr Hlth, Dept Biochem, Ctr Vasc Biol, Storrs, CT 06269 USA

来源：

GYNECOLOGIC ONCOLOGY | 2005年 / 99卷 / 01期

基金：

芬兰科学院;

关键词：

HuR; COX-2; inhibin-alpha; ovarian cancer; mucinous;

D O I：

10.1016/j.ygyno.2005.04.047

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cyclooxygenase-2 (COX-2) expression has been found to associate with poor prognosis in several types of carcinomas. HuR is an mRNA stability protein and it regulates the expression of COX-2. Objectives and methods. We analyzed the expression of COX-2 and HuR in 64 mucinous ovarian carcinoma specimens by immunohistochemistry. Results. In mucinous tumors, high COX-2 protein expression was found in epithelial cancer cells in 39% (22/56) and in stromal cells in 24% (13/55) of the specimens. The expression of COX-2 in cancer cells correlated with high grade (P = 0.0285), but stromal COX-2 expression had no correlation with any clinical parameter tested. Cytoplasmic HuR protein expression was observed in cancer cells in 47% (27/57) and in stromal cells in 7% (4/56) of the mucinous tumors, and it correlated with COX-2 expression in the cancer cells (P = 0.0162) but not in the stroma. Conclusion. Our results support the hypothesis that cytoplasmic HuR is connected to COX-2 expression in ovarian carcinoma, but that its role is restricted to the transformed epithelial cancer cells. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：14 / 19

页数：6

共 39 条

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