Neuroendocrinology of ageing

被引：81

作者：

Rehman, HU

Masson, EA

机构：

[1] Hull Royal Infirm, Dept Med, Kingston Upon Hull HU3 2JZ, N Humberside, England

[2] Hull Royal Infirm, Dept Endocrinol & Diabet, Kingston Upon Hull HU3 2JZ, N Humberside, England

来源：

AGE AND AGEING | 2001年 / 30卷 / 04期

关键词：

ageing; hypothalamic neuroendocrine system;

D O I：

10.1093/ageing/30.4.279

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Many common problems encountered in the ageing patient can be related to neuroendocrine phenomena. These include Alzheimer's disease, dementia and cognitive dysfunction, depression, Parkinson's disease, hyponatraemia and the postmenopausal increase in both vascular risk and osteoporosis. This review concentrates on the hypothalamic neuroendocrine system, including the dopaminergic, noradrenergic, serotoninergic, cholinergic and neurohypophyseal systems and the roles of the anterior pituitary and monoamine oxidases, luteinizing hormone-releasing hormone, corticotrophin-releasing factor, the pro-opiomelanocortin-derived and opioid peptides, peptides involved in growth hormone and thyrotropin regulation, and amino acid transmitters.

引用

页码：279 / 287

页数：9

共 96 条

[1] EVIDENCE THAT A DECREASE IN OPIOID TONE MAY EVOKE PREOVULATORY LUTEINIZING-HORMONE RELEASE IN THE RAT [J].