Renal potassium-chloride cotransporters

被引：23

作者：

Mount, DB

Gamba, G

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Med, Div Nephrol & Hypertens, Nashville, TN 37232 USA

[2] Nashville Vet Affairs Med Ctr, Nashville, TN USA

[3] Univ Nacl Autonoma Mexico, Salvador Zubiran Natl Inst Med Sci & Nutr, Mol Physiol Unit, Mexico City 04510, DF, Mexico

[4] Univ Nacl Autonoma Mexico, Inst Biomed Res, Mexico City 04510, DF, Mexico

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 2001年 / 10卷 / 05期

关键词：

D O I：

10.1097/00041552-200109000-00021

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The electroneutral cotransport of potassium and chloride is mediated by potassium-chloride transporters, which are encoded by members of the gene family of cation-chloride cotransporters. A significant body of evidence argues for swelling-activated, basolateral potassium-chloride transport in the proximal tubule and thick ascending limb, with a potential role in transepithelial salt transport. However, the lack of specific inhibitors has impeded progress in this area. The cloning of the four potassium-chloride cotransporter genes has sparked new interest in this transport pathway, and promises to yield novel insights into their roles in cellular and renal physiology. Curr Opin Nephrol Hypertens 10:685-691. (C) 2001 Lippincott Williams & Wilkins.

引用

页码：685 / 691

页数：7

共 70 条

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