ERK-1/2 activity is required for efficient RSV infection

被引：37

作者：

Kong, XY

San Juan, H

Behera, A

Peeples, ME

Wu, J

Lockey, RF

Mohapatra, SS

机构：

[1] Joy McCann Culverhouse Airways Dis Res Ctr, Div Allergy & Immunol, Dept Internal Med, Tampa, FL 33612 USA

[2] Univ S Florida, Coll Med, Dept Med Microbiol & Immunol, Tampa, FL 33612 USA

[3] VA Hosp, Tampa, FL 33612 USA

[4] Univ Del Norte, Barranquilla, Colombia

[5] Rush Med Coll, Chicago, IL 60612 USA

[6] H Lee Moffitt Canc Ctr, Tampa, FL 33682 USA

来源：

FEBS LETTERS | 2004年 / 559卷 / 1-3期

关键词：

respiratory syncytial virus; signal transducer and activator of transcription-1 alpha; extracellular signal-regulated kinase; bronchial epithelial cell;

D O I：

10.1016/S0014-5793(04)00002-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Respiratory syncytial virus (RSV) infection up-regulates the expression of genes encoding proinflammatory mediators in bronchial epithelial cells. However, the specific signaling events immediately following RSV exposure are poorly understood. Herein, we report that RSV attachment to A549 cells activates both ERK-1 and ERK-2 pathways within 5 min. Inhibition of ERK pathways significantly decreases RSV infection of these cells compared to controls. These results demonstrate that the activation of the ERK-1/2 is required in RSV-induced early gene expression. (C) 2004 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

引用

收藏

页码：33 / 38

页数：6

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