An overview of values for the threshold of toxicological concern

被引：28

作者：

Hennes, E. C. ^{[1
]}

机构：

[1] European Ctr Ecotoxicol & Toxicol Chem ECETOC, B-1160 Brussels, Belgium

来源：

TOXICOLOGY LETTERS | 2012年 / 211卷 / 03期

关键词：

Threshold of toxicological concern; Toxicological endpoint; Exposure route; Risk assessment; DERMAL SENSITIZATION THRESHOLD; CONCERN TTC; SAFETY EVALUATION; RISK-ASSESSMENT; GENOTOXIC IMPURITIES; CARCINOGENIC POTENCY; CHEMICAL-STRUCTURE; SUBSTANCES PRESENT; EUROPEAN-UNION; FOOD-ADDITIVES;

D O I：

10.1016/j.toxlet.2012.03.795

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

An overview of values for the threshold of toxicological concern (TTC) is presented. This comprises the more established TTC values, including those that have been endorsed by regulatory bodies, and those that have more recently been proposed and may still need further development. The overview is structured by use/exposure scenario and provides, in particular, key information on the underlying databases. It is aimed to support the application of the TTC approach in the risk assessment of chemicals whereby it is important to be aware under which circumstances a certain TTC value can be applied. Some recommendations for potential future developments to further improve the TTC approach are also being made. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：296 / 303

页数：8

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