Neurotransmitter release mechanisms studied in Caenorhabditis elegans

被引：30

作者：

Barclay, Jeff W. ^{[1
]}

Morgan, Alan ^{[1
]}

Burgoyne, Robert D. ^{[1
]}

机构：

[1] Univ Liverpool, Physiol Lab, Inst Translat Med, Liverpool L69 3BX, Merseyside, England

来源：

CELL CALCIUM | 2012年 / 52卷 / 3-4期

关键词：

Exocytosis; C; elegans; Presynaptic; Vesicle fusion; SNARE; Munc18; DENSE CORE VESICLES; SYNAPTIC-TRANSMISSION; MEMBRANE-FUSION; ACTIVE ZONE; CA2+ SENSOR; SYNTAXIN; PROTEIN; MUNC18-1; EXOCYTOSIS; UNC-13;

D O I：

10.1016/j.ceca.2012.03.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The process of regulated exocytosis has received considerable interest as a key component of synaptic transmission. Fusion of presynaptic vesicles and the subsequent release of their neurotransmitter contents is driven by a series of interactions between evolutionarily conserved proteins. Key insights into the molecular mechanisms of vesicle fusion have come from research using genetic model systems such as the nematode worm Caenorhabditis elegans. We review here the current knowledge regarding regulated exocytosis at the C. elegans synapse and future research directions involving this model organism. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：289 / 295

页数：7

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