Electrochemically-responsive magnetic nanoparticles for reversible protein adsorption

被引：19

作者：

Guo, Jun ^{[1
]}

Wang, Niejun ^{[1
]}

Peng, Liao ^{[1
]}

Wu, Jingjun ^{[2
]}

Ye, Qiquan ^{[1
]}

Feng, Anchao ^{[1
]}

Wang, Zhipeng ^{[1
]}

Zhang, Chong ^{[2
]}

Xing, Xin-Hui ^{[2
]}

Yuan, Jinying ^{[1
,3
]}

机构：

[1] Tsinghua Univ, Dept Chem, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China

[2] Tsinghua Univ, Dept Chem Engn, Inst Biochem Engn, Key Lab Ind Biocatalysis,Minist Educ, Beijing 100084, Peoples R China

[3] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2016年 / 4卷 / 22期

基金：

中国国家自然科学基金;

关键词：

IRON-OXIDE NANOPARTICLES; BOVINE SERUM-ALBUMIN; BETA-CYCLODEXTRIN; FE3O4; NANOPARTICLES; FACILE SYNTHESIS; BLOCK-COPOLYMER; REDOX; IMMOBILIZATION; SEPARATION; POLYMER;

D O I：

10.1039/c6tb00259e

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

082905 [生物质能源与材料]; 100103 [病原生物学];

摘要：

Electrochemical stimulus is a clean and simple choice of stimulating source in the field of stimulir-esponsive materials. Herein, we report an electrochemically-responsive hybrid assembly of magnetic nanoparticles (Fe3O4@SiO2-PGMA-CD) and polyethylene glycol-Fc (PEG-Fc) based on the host-guest interaction between beta-cyclodextrin and ferrocene groups. Through electrochemical control, the hydrophilic polymer chains can be reversibly linked to or dropped off from the surface of the magnetic nanoparticles. Thus, the hydrophobic property of the surface together with the protein adsorption ability of the magnetic nanoparticles can be conveniently adjusted by voltages applied. A reversible protein adsorption/release transition from this novel hybrid material has been realized, demonstrated by the bovine serum albumin adsorption experiment. Therefore, an elegant material is introduced to achieve electrochemically-controlled reversible magnetic separation of proteins.

引用

页码：4009 / 4016

页数：8

共 58 条

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Ultrathin poly(N-isopropylacrylamide) grafted layer on polystyrene surfaces for cell adhesion/detachment control [J].