New therapies for hepatitis C

被引:22
作者
Modi, Apurva A. [1 ]
Hoofnagle, Jay H. [1 ]
机构
[1] NIDDK, Liver Dis Branch, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1002/hep.21892
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
引用
收藏
页码:615 / 617
页数:3
相关论文
共 22 条
[1]   Valopicitabine (NM283), alone or with peginterferon, compared to peg interferon/ribavirin (pegIFN/RBV) retreatment in patients with HCV-1 infection and prior non-response to pegIFN/RBV: One-year results [J].
Afdhal, N. ;
O'Brien, C. ;
Godofsky, E. ;
Rodriguez-Torres, M. ;
Pappas, S. C. ;
Lawitz, E. ;
Pockros, P. ;
Sulkowski, M. ;
Jacobson, I. ;
Chao, G. ;
Knox, S. ;
Pietropaolo, K. ;
Brown, N. A. .
JOURNAL OF HEPATOLOGY, 2007, 46 :S5-S5
[2]   Ascending multiple-dose pharmacokinetics of viramidine, a prodrug of ribavirin, in adult subjects with compensated hepatitis C infection [J].
Aora, S ;
Xu, C ;
Teng, A ;
Peterson, J ;
Yeh, LT ;
Gish, R ;
Lou, D ;
Rossi, S ;
Lin, C .
JOURNAL OF CLINICAL PHARMACOLOGY, 2005, 45 (03) :275-285
[3]   A phase 2 study to evaluate the antiviral activity, safety, and pharmacokinetics of recombinant human albumin-interferon alfa fusion protein in genotype 1 chronic hepatitis C patients [J].
Bain, VG ;
Kaita, KD ;
Yoshida, EM ;
Swain, MG ;
Heathcote, EJ ;
Neumann, AU ;
Fiscella, M ;
Yu, R ;
Osborn, BL ;
Cronin, PW ;
Freimuth, WW ;
McHutchison, JG ;
Subramanian, GM .
JOURNAL OF HEPATOLOGY, 2006, 44 (04) :671-678
[4]   NONSTRUCTURAL PROTEIN-3 OF THE HEPATITIS-C VIRUS ENCODES A SERINE-TYPE PROTEINASE REQUIRED FOR CLEAVAGE AT THE NS3/4 AND NS4/5 JUNCTIONS [J].
BARTENSCHLAGER, R ;
AHLBORNLAAKE, L ;
MOUS, J ;
JACOBSEN, H .
JOURNAL OF VIROLOGY, 1993, 67 (07) :3835-3844
[5]  
FORESTIER N, 2007, HEPATOLOGY, V46
[6]   Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. [J].
Fried, MW ;
Shiffman, ML ;
Reddy, KR ;
Smith, C ;
Marinos, G ;
Goncales, FL ;
Haussinger, D ;
Diago, M ;
Carosi, G ;
Dhumeaux, D ;
Craxi, A ;
Lin, A ;
Hoffman, J ;
Yu, J .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (13) :975-982
[7]   Peginterferon and ribavirin for chronic hepatitis C [J].
Hoofnagle, Jay H. ;
Seeff, Leonard B. .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (23) :2444-2451
[8]  
KIEFFER T, 2007, HEPATOLOGY, V46
[9]   An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus [J].
Lamarre, D ;
Anderson, PC ;
Bailey, M ;
Beaulieu, P ;
Bolger, G ;
Bonneau, P ;
Bös, M ;
Cameron, DR ;
Cartier, M ;
Cordingley, MG ;
Faucher, AM ;
Goudreau, N ;
Kawai, SH ;
Kukolj, G ;
Lagacé, L ;
LaPlante, SR ;
Narjes, H ;
Poupart, MA ;
Rancourt, J ;
Sentjens, RE ;
St George, R ;
Simoneau, B ;
Steinmann, G ;
Thibeault, D ;
Tsantrizos, YS ;
Weldon, SM ;
Yong, CL ;
Llinàs-Brunet, M .
NATURE, 2003, 426 (6963) :186-189
[10]   Clearance of HCV RNA with valopicitabine (NM283) plus peg-interferon in treatment-naive patients with HCV-1 infection: Results at 24 and 48 weeks [J].
Lawitz, E. ;
Nguyen, T. ;
Younes, Z. ;
Santoro, J. ;
Gitlin, N. ;
McEniry, D. ;
Chasen, R. ;
Goff, J. ;
Dieterich, D. ;
Knox, S. ;
Kleber, K. ;
Belanger, B. ;
Brown, N. A. ;
Grp, Investigator .
JOURNAL OF HEPATOLOGY, 2007, 46 :S9-S9