Hybrid immunoaffinity-mass spectrometric methods for efficient protein biomarker verification in pharmaceutical development

被引：12

作者：

Ackermann, Bradley L. ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Corp Ctr, Indianapolis, IN 46285 USA

来源：

BIOANALYSIS | 2009年 / 1卷 / 02期

关键词：

STABLE-ISOTOPE DILUTION; QUANTITATIVE-ANALYSIS; QUANTIFICATION; PEPTIDES; VALIDATION; DISCOVERY; LC/MS/MS; MS;

D O I：

10.4155/BIO.09.49

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：265 / 268

页数：4

共 13 条

[1] Coupling immunoaffinity techniques with MS for quantitative analysis of low-abundance protein biomarkers [J].

Ackermann, Bradley L. ;

Berna, Michael J. .

EXPERT REVIEW OF PROTEOMICS, 2007, 4 (02) :175-186

[2] Mass spectrometric quantitation of peptides and proteins using stable isotope standards and capture by anti-peptide antibodies (SISCAPA) [J].

Anderson, NL ;

Anderson, NG ;

Haines, LR ;

Hardie, DB ;

Olafson, RW ;

Pearson, TW .

JOURNAL OF PROTEOME RESEARCH, 2004, 3 (02) :235-244

[3] Quantification of NTproBNP in rat serum using immunciprecipitation and LC/MS/MS: a biomarker of drug-induced cardiac hypertrophy [J].

Berna, Michael ;

Ott, Lee ;

Engle, Steve ;

Watson, David ;

Solter, Philip ;

Ackermann, Bradley .

ANALYTICAL CHEMISTRY, 2008, 80 (03) :561-566

[4] Strategic use of immunoprecipitation and LC/MS/MS for trace-level protein quantification: Myosin light chain 1, a biomarker of cardiac necrosis [J].

Berna, Michael J. ;

Zhen, Yuejun ;

Watson, David E. ;

Hale, John E. ;

Ackermann, Bradley L. .

ANALYTICAL CHEMISTRY, 2007, 79 (11) :4199-4205

[5] Protein Quantitation through Targeted Mass Spectrometry: The Way Out of Biomarker Purgatory? [J].

Carr, Steven A. ;

Anderson, Leigh .

CLINICAL CHEMISTRY, 2008, 54 (11) :1749-1752

[6] Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS [J].

Gerber, SA ;

Rush, J ;

Stemman, O ;

Kirschner, MW ;

Gygi, SP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (12) :6940-6945

[7] Quantitative, multiplexed assays for low abundance proteins in plasma by targeted mass spectrometry and stable isotope dilution [J].

Keshishian, Hasmik ;

Addona, Terri ;

Burgess, Michael ;

Kuhn, Eric ;

Carr, Steven A. .

MOLECULAR & CELLULAR PROTEOMICS, 2007, 6 (12) :2212-2229

[8] Fit-for-purpose method development and validation for successful biomarker measurement [J].

Lee, JW ;

Devanarayan, V ;

Barrett, YC ;

Weiner, R ;

Allinson, J ;

Fountain, S ;

Keller, S ;

Weinryb, I ;

Green, M ;

Duan, L ;

Rogers, JA ;

Millham, R ;

O'Brien, PJ ;

Sailstad, J ;

Khan, M ;

Ray, C ;

Wagner, JA .

PHARMACEUTICAL RESEARCH, 2006, 23 (02) :312-328

[9] Quantitative analysis of amyloid β peptides in cerebrospinal fluid of Alzheimer's disease patients by immunoaffinity purification and stable isotope dilution liquid chromatography/negative electrospray ionization tandem mass spectrometry [J].

Oe, Tomoyuki ;

Ackermann, Bradley L. ;

Inoue, Koichi ;

Berna, Michael J. ;

Garner, Carlos O. ;

Gelfanova, Valentina ;

Dean, Robert A. ;

Siemers, Eric R. ;

Holtzman, David M. ;

Farlow, Martin R. ;

Blair, Ian A. .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2006, 20 (24) :3723-3735

[10] Protein biomarker discovery and validation: the long and uncertain path to clinical utility [J].

Rifai, Nader ;

Gillette, Michael A. ;

Carr, Steven A. .

NATURE BIOTECHNOLOGY, 2006, 24 (08) :971-983

← 1 2 →