Rapamune® (RAPA, rapamycin, sirolimus):: Mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression

被引：561

作者：

Sehgal, SN ^{[1
]}

机构：

[1] Wyeth Ayerst Res, Princeton, NJ 08543 USA

来源：

CLINICAL BIOCHEMISTRY | 1998年 / 31卷 / 05期

关键词：

rapamycin; sirolimus; cellular proliferation; immunosuppression; organ transplantation; signal transduction; mTOR; p70s6; kinase; PHAS; 1; cyclin-dependent kinases;

D O I：

10.1016/S0009-9120(98)00045-9

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Rapamune is a novel immunosuppressive agent in Phase III clinical trial in renal transplantation. Its unique mechanism of action has created great interest in its use as a biochemical probe of signal transduction pathways that has provided insight into its molecular mechanism of action. This article reviews the current state of our understanding of the mechanism of action of rapamune. Copyright (C) 1998 The Canadian Society of Clinical Chemists.

引用

页码：335 / 340

页数：6

共 69 条

[1]

AAGUAARDTILLERY KM, 1994, CELL IMMUNOL, V152, P493

[2] Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor beta c chain [J].