Nuclear Speckles

被引：565

作者：

Spector, David L. ^{[1
]}

Lamond, Angus I. ^{[2
]}

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

[2] Univ Dundee, Coll Life Sci, Wellcome Trust Ctr Gene Regulat & Express, Dundee DD1 5EH, Scotland

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2011年 / 3卷 / 02期

关键词：

RNA-POLYMERASE-II; INTERCHROMATIN GRANULE CLUSTERS; MAMMALIAN-CELL NUCLEUS; SPLICING FACTORS; SC-35; DOMAINS; SERINE-RICH; IN-VIVO; SUBNUCLEAR LOCALIZATION; PROTEOMIC ANALYSIS; POLY(A) RNA;

D O I：

10.1101/cshperspect.a000646

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nuclear speckles, also known as interchromatin granule clusters, are nuclear domains enriched in pre-mRNA splicing factors, located in the interchromatin regions of the nucleoplasm of mammalian cells. When observed by immunofluorescence microscopy, they usually appear as 20-50 irregularly shaped structures that vary in size. Speckles are dynamic structures, and their constituents can exchange continuously with the nucleoplasm and other nuclear locations, including active transcription sites. Studies on the composition, structure, and dynamics of speckles have provided an important paradigm for understanding the functional organization of the nucleus and the dynamics of the gene expression machinery.

引用

页码：1 / 12

页数：12

共 111 条

[1]

BECK JS, 1961, LANCET, V1, P1203

[2] A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression [J].

Bernard, Delphine ;

Prasanth, Kannanganattu V. ;

Tripathi, Vidisha ;

Colasse, Sabrina ;

Nakamura, Tetsuya ;

Xuan, Zhenyu ;

Zhang, Michael Q. ;

Sedel, Frederic ;

Jourdren, Laurent ;

Coulpier, Fanny ;

Triller, Antoine ;

Spector, David L. ;

Bessis, Alain .

EMBO JOURNAL, 2010, 29 (18) :3082-3093

[3] Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors [J].

Boronenkov, IV ;

Loijens, JC ;

Umeda, M ;

Anderson, RA .

MOLECULAR BIOLOGY OF THE CELL, 1998, 9 (12) :3547-3560

[4] PSKH1, a novel splice factor compartment-associated serine kinase [J].

Brede, G ;

Solheim, J ;

Prydz, H .

NUCLEIC ACIDS RESEARCH, 2002, 30 (23) :5301-5309

[5] TRANSCRIPTION-DEPENDENT REDISTRIBUTION OF THE LARGE SUBUNIT OF RNA-POLYMERASE-II TO DISCRETE NUCLEAR DOMAINS [J].

BREGMAN, DB ;

DU, L ;

VANDERZEE, S ;

WARREN, SL .

JOURNAL OF CELL BIOLOGY, 1995, 129 (02) :287-298

[6] DYNAMIC ORGANIZATION OF SPLICING FACTORS IN ADENOVIRUS-INFECTED CELLS [J].

BRIDGE, E ;

XIA, DX ;

CARMOFONSECA, M ;

CARDINALI, B ;

LAMOND, AI ;

PETTERSSON, U .

JOURNAL OF VIROLOGY, 1995, 69 (01) :281-290

[7] Association between active genes occurs at nuclear speckles and is modulated by chromatin environment [J].

Brown, Jill M. ;

Green, Joanne ;

das Neves, Ricardo Pires ;

Wallace, Helen A. C. ;

Smith, Andrew J. H. ;

Hughes, Jim ;

Gray, Nicki ;

Taylor, Steve ;

Wood, William G. ;

Higgs, Douglas R. ;

Iborra, Francisco J. ;

Buckle, Veronica J. .

JOURNAL OF CELL BIOLOGY, 2008, 182 (06) :1083-1097

[8] Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity [J].

Caceres, JF ;

Misteli, T ;

Screaton, GR ;

Spector, DL ;

Krainer, AR .

JOURNAL OF CELL BIOLOGY, 1997, 138 (02) :225-238

[9]

Cajal S., 1910, Trab Lab Invest Biol Univ Madrid, V8, P27

[10] DISCRETE NUCLEAR DOMAINS OF POLY(A) RNA AND THEIR RELATIONSHIP TO THE FUNCTIONAL-ORGANIZATION OF THE NUCLEUS [J].

CARTER, KC ;

TANEJA, KL ;

LAWRENCE, JB .

JOURNAL OF CELL BIOLOGY, 1991, 115 (05) :1191-1202

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