Recurrent triploidy of maternal origin

被引：29

作者：

Brancati, F

Mingarelli, R

Dallapiccola, B

机构：

[1] CSS Mendel Inst, I-00198 Rome, Italy

[2] CSS Hosp, IRCCS, San Giovanni Rotondo, Italy

[3] Univ Roma La Sapienza, Dept Expt Med & Pathol, Rome, Italy

来源：

EUROPEAN JOURNAL OF HUMAN GENETICS | 2003年 / 11卷 / 12期

关键词：

triploidy; digyny; recurrent abortion;

D O I：

10.1038/sj.ejhg.5201076

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Triploidy is the most frequent chromosome aberration in first trimester spontaneous abortions. In contrast to aneuploidies due to nondisjunction, increased maternal age is not a risk factor and the mechanism of triploidy remains poorly understood. To date, recurrence of triploidy of maternal origin has been described only in a few families suggesting some underlying genetic factors. Here, we report on a woman who underwent three consecutive triploid pregnancies, in two of which maternal origin of triploidy was proved by molecular analysis.

引用

页码：972 / 974

页数：3

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