The Effect of Liver Hydrolysate on Chronic Ethanol-Induced Hepatic Injury in Normal Rats

被引：9

作者：

Yamada, Kotaro ^{[1
]}

Ueda, Kazuma ^{[2
]}

Shirakawa, Hitoshi ^{[2
]}

Giriwono, Puspo Edi ^{[2
,3
]}

Honda, Satoru ^{[1
]}

Sakurai, Hidetomo ^{[1
]}

Komai, Michio ^{[2
]}

机构：

[1] Zeria Pharmaceut Co Ltd, Consumer Hlth Prod Dev, Chuo Ku, 10-11 Nihonbashi,Kobuna Cho, Tokyo 1038351, Japan

[2] Tohoku Univ, Grad Sch Agr Sci, Lab Nutr, Aoba Ku, 468-1 Aramaki Aza Aoba, Sendai, Miyagi 9808572, Japan

[3] IPB Univ, Dept Food Sci & Technol, Fac Agr Technol, Jl Raya Dramaga,Kampus IPB Dramaga, Bogor 16680, Indonesia

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2020年 / 43卷 / 03期

关键词：

chronic ethanol; liver damage; liver hydrolysate; oxidative stress; ANTIOXIDANT ACTIVITY; OXIDATIVE STRESS; ALCOHOL; METABOLISM;

D O I：

10.1248/bpb.b19-00848

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The mechanism underlying the improvement in hepatic function by liver hydrolysate (LH) after ethanol-induced hepatic injury is unclear. Therefore, we investigated the effects of LH administration on chronic ethanol-induced hepatic injury in normal rats and the mechanism underlying the improvement of its symptoms by LH. LH attenuated liver damage and reduced oxidative stress after chronic ethanol-induced hepatic injury in normal rats. LH treatment reduced hepatic injury biomarkers of plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT). LH treatment also decreased levels of 8-hydroxy-deoxyguanosine (8-OHdG) as oxidative stress marker. LH may prove beneficial to prevent the liver damage of chronic ethanol, at least in part, by alleviating oxidative stress.

引用

页码：554 / 557

页数：4

共 25 条

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