Orthogonally protected dialkynes

被引：39

作者：

Ernst, A ^{[1
]}

Gobbi, L ^{[1
]}

Vasella, A ^{[1
]}

机构：

[1] ETH ZURICH,ORGAN CHEM LAB,ETH ZENTRUM,CH-8092 ZURICH,SWITZERLAND

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 44期

关键词：

D O I：

10.1016/0040-4039(96)01838-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several C-SiMe(3) and C-GeMe(3) protected dialkynes have been synthesized and regioselectively deprotected by protodesilylation or protodegermylation. Catalytic amounts of CuBr in THF/MeOH or in aqueous acetone lead exclusively to protodegermylation. The Me(3)Si group was removed with KF/[18]-crown-6 in aqueous THF without affecting the GeMe(3) group. C-SiMe(3) protected propargyl ethers are also selectively cleaved with K2CO3 in THF/MeOH. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：7959 / 7962

页数：4

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