Activation and coreceptor expression of T lymphocytes in HIV/AIDS patients of China

被引：9

作者：

Shang, H ^{[1
]}

Zhang, ZN ^{[1
]}

Jiang, YJ ^{[1
]}

Han, XO ^{[1
]}

Wang, YN ^{[1
]}

Zhang, M ^{[1
]}

Ye, XH ^{[1
]}

Liu, Y ^{[1
]}

Diao, YY ^{[1
]}

Dai, D ^{[1
]}

Geng, WQ ^{[1
]}

机构：

[1] China Med Univ, AIDS Res Ctr, Affiliated Hosp 1, Shenyang 110001, Peoples R China

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2005年 / 25卷 / 01期

关键词：

HIV-1; activation; HLA-DR; CD38; coreceptor; CCR5; CXCR4;

D O I：

10.1007/s10875-005-0359-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The objective of this paper was to investigate the activation and coreceptor CCR5, CXCR4 expression of T lymphocytes in HIV/AIDS patients of China, and to study their association with disease progression. Seventy-seven HIV/AIDS patients and thirteen normal controls were enrolled and three-color flow-cytometry was used to detect the activation marker HLA-DR, CD38 and the coreceptor CCR5, CXCR4 expression on T lymphocytes in whole blood samples taken from the patients and the controls. The HLA-DR, CD38 and CCR5 expression on CD4, CD8(+) T cells in AIDS patients was higher than in asymptomatic HIV-1 infected patients and normal controls ( p < 0.05); The activation and CCR5 expression on T lymphocytes significantly correlated with CD4(+) T lymphocyte number and viral load. The activation on T lymphocytes and the expression of CCR5 on T lymphocytes in HIV/AIDS patients of China are significantly correlated with disease progression.

引用

页码：68 / 72

页数：5

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