Palladium-mediated synthesis of novel nimesulide derivatives

被引：14

作者：

Durgadas, Shylaprasad ^{[2
,3
]}

Chatare, Vijay Kumar ^{[1
]}

Mukkanti, Khagga ^{[2
]}

Pal, Sarbani ^{[1
]}

机构：

[1] MNR Degree & PG Coll, Dept Chem, Hyderabad 500072, Andhra Pradesh, India

[2] J N T Univ, Hyderabad 500072, Andhra Pradesh, India

[3] MSN Pharmachem Pvt Ltd, APIICL, Patancheru M 502307, Andhra Pradesh, India

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2010年 / 24卷 / 10期

关键词：

nimesulide; anti-inflammatory; C-C bond; palladium; alkyne; alkene; boronic acid; ARYL;

D O I：

10.1002/aoc.1666

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Synthesis of a series of compounds structurally related to the anti-inflammatory agent nimesulide has been accomplished via Pd-catalyzed C-C bond forming reactions. Thus 4-iodo derivative, prepared from nimesulide, participated in Sonogashira (copper-free), Heck and Suzuki coupling reactions to afford the corresponding alkynyl, alkenyl and aryl substituted products. Some of the compounds synthesized were tested for anti-inflammatory activities in vivo. Copyright (C) 2010 John Wiley & Sons, Ltd.

引用

页码：680 / 684

页数：5

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