High dose methylprednisolone and rituximab is an effective therapy in advanced refractory chronic lymphocytic leukemia resistant to fludarabine therapy

被引：51

作者：

Dungarwalla, Moez ^{[1
]}

Evans, Steve O. ^{[1
]}

Riley, Unell ^{[1
]}

Catovsky, Daniel ^{[1
]}

Dearden, Clare E. ^{[1
]}

Matutes, Estella ^{[1
]}

机构：

[1] Royal Marsden Hosp, Haematooncol Unit, Sutton, Surrey, England

来源：

HAEMATOLOGICA | 2008年 / 93卷 / 03期

关键词：

D O I：

10.3324/haematol.11903

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The combination of high dose methylprednisolone and rituximab induces superior overall (93%) and complete (14%) response rates compared to high dose methylprednisolone alone (overall 43%, complete remission 0%) in heavily pre-treated chronic lymphocytic leukemia patients with advanced disease. Despite its efficacy the combination is not easily manageable because of the high rate of opportunistic infections.

引用

页码：475 / 476

页数：2

共 10 条

[1] National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: Revised guidelines for diagnosis and treatment [J].

Cheson, BD ;

Bennett, JM ;

Grever, M ;

Kay, N ;

Keating, MJ ;

OBrien, S ;

Rai, KR .

BLOOD, 1996, 87 (12) :4990-4997

[2] Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia [J].

Cornely, Oliver A. ;

Maertens, Johan ;

Winston, Drew J. ;

Perfect, John ;

Ullmann, Andrew J. ;

Walsh, Thomas J. ;

Helfgott, David ;

Holowiecki, Jerzy ;

Stockelberg, Dick ;

Goh, Yeow-Tee ;

Petrini, Mario ;

Hardalo, Cathy ;

Suresh, Ramachandran ;

Angulo-Gonzalez, David .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (04) :348-359

[3] Itraconazole prevents invasive fungal infections in neutropenic patients treated for hematologic malignancies:: Evidence from a meta-analysis of 3,597 patients [J].

Glasmacher, A ;

Prentice, A ;

Gorschlüter, M ;

Engelhart, S ;

Hahn, C ;

Djulbegovic, B ;

Schmidt-Wolf, IGH .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (24) :4615-4626

[4] Protease activation and glucocorticoid-induced apoptosis in chronic lymphocytic leukemia [J].

McConkey, DJ ;

Chandra, J .

LEUKEMIA & LYMPHOMA, 1999, 33 (5-6) :421-+

[5] INFECTIONS IN CHRONIC LYMPHOCYTIC-LEUKEMIA - RISK-FACTORS, AND IMPACT ON SURVIVAL, AND TREATMENT [J].

MOLICA, S .

LEUKEMIA & LYMPHOMA, 1994, 13 (3-4) :203-214

[6] Modulations of glucocorticoid-induced apoptosis linked to the p53 deletion and to the apoptosis susceptibility gene Rapop1 (Radiation-induced apoptosis 1) [J].

Mori, N ;

Yamate, J ;

Stassen, APM ;

Oka, S ;

Okumoto, H ;

Tsubura, A ;

Akamatsu, T ;

Sakuma, S ;

Demant, P .

ONCOGENE, 1999, 18 (29) :4282-4285

[7]

Riccardi C, 2000, THERAPIE, V55, P165

[8]

Smets LA, 1999, ADV EXP MED BIOL, V457, P607

[9] High dose methylprednisolone can induce remissions in CLL patients with p53 abnormalities [J].

Thornton, PD ;

Matutes, E ;

Bosanquet, AG ;

Lakhani, AK ;

Grech, H ;

Ropner, JE ;

Joshi, R ;

Mackie, PH ;

Douglas, IDC ;

Bowcock, SJ ;

Catovsky, D .

ANNALS OF HEMATOLOGY, 2003, 82 (12) :759-765

[10] High dose methyl prednisolone in refractory chronic lymphocytic leukaemia [J].

Thornton, PD ;

Hamblin, M ;

Treleaven, JG ;

Matutes, E ;

Lakhani, AK ;

Catovsky, D .

LEUKEMIA & LYMPHOMA, 1999, 34 (1-2) :167-170

← 1 →