Evolution of microglial activation in patients after ischemic stroke:: a [11C](R)-PK11195 PET study

被引：214

作者：

Gerhard, A

Schwarz, J

Myers, R

Wise, R

Banati, RB

机构：

[1] Hammersmith Hosp, Hammersmith Imanet, London W12 0NN, England

[2] Univ Leipzig, Dept Neurol, D-7010 Leipzig, Germany

[3] Univ Ulm, Dept Neurol, D-7900 Ulm, Germany

[4] Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Neuropathol, London, England

[5] Univ London Imperial Coll Sci Technol & Med, Fac Med, MRC, Ctr Clin Sci, London, England

[6] Univ Sydney, Sch Med Radiat Sci, BMRI, Clive & Vera Ramaciotti Ctr Brain Imaging, Sydney, NSW 1825, Australia

来源：

NEUROIMAGE | 2005年 / 24卷 / 02期

关键词：

ischemic stroke; peripheral benzodiazepine binding site; activated microglia; C-11](R)-PK11195 PET;

D O I：

10.1016/j.neuroimage.2004.09.034

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We obtained [C-11](R)-PK11195 PET scans in six patients at different time points between 3 and 150 days after onset of ischemic stroke in order to measure the time course of microglial activation. Increased [C-11](R)-PK11195 binding around the lesion was observed as early as 3 days. Scans at later time points showed ongoing changes in the distribution of the [C-11](R)-PK11195 signal, involving the area of the primary lesion and areas distant from the primary lesion site. Our data suggest that [C-11](R)-PK11195 PET can be used to investigate both the primary lesion and remote pathological changes following Wallerian degeneration. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：591 / 595

页数：5

共 25 条

[1] SURVEILLANCE, INTERVENTION AND CYTOTOXICITY - IS THERE A PROTECTIVE ROLE OF MICROGLIA [J].