Kurstakins:: A new class of lipopeptides isolated from Bacillus thuringiensis

被引：121

作者：

Hathout, Y ^{[1
]}

Ho, YP ^{[1
]}

Ryzhov, V ^{[1
]}

Demirev, P ^{[1
]}

Fenselau, C ^{[1
]}

机构：

[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 11期

关键词：

D O I：

10.1021/np000169q

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A novel class of Lipopeptides was isolated from Bacillus thuringiensis kurstaki HD-1. Four compounds (1-4) were separated by high-performance liquid chromatography and their primary structures determined using a combination of chemical reactions and mass spectrometry. The four Lipopeptides were found to have the same amino acid sequence, Thr-Gly-Ala-Ser-His-Gln-Gln, but different fatty acids. The fatty acyl chain is linked to the N-terminal amino acid residue via an amide bond. Each lipopeptide has a lactone linkage between the carboxyl terminal amino acid and the hydroxyl group in the side chain of the serine residue. Antifungal activity was demonstrated against Stachybotrys charatum.

引用

页码：1492 / 1496

页数：5

共 29 条

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