Solid-phase synthesis and solution structure of bicyclic β-turn peptidomimetics:: diversity at the i position

被引：29

作者：

Eguchi, M

Lee, MS

Stasiak, M

Kahn, M

机构：

[1] Molecumet Ltd, Bellevue, WA 98005 USA

[2] Univ Washington, Dept Pathobiol, Seattle, WA 98195 USA

[3] Pacific NW Res Inst, Seattle, WA 98122 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 07期

关键词：

peptide analogues/mimetics; combinatorial chemistry; bicyclic heterocyclic compounds;

D O I：

10.1016/S0040-4039(00)02248-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A library of the urea type 6,6-bicyclic beta -turn mimetics was conveniently prepared by using solid-phase chemistry with diversity at the i position in good yield and purity. The solution structure of the urea type scaffold was shown to mimic a type I beta -turn structure. (C) 2001 Elsevier Science Ltd. All rights reserved.

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收藏

页码：1237 / 1239

页数：3

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