CSF Aβ42 and tau in Parkinson's Disease with Cognitive Impairment

被引：142

作者：

Montine, Thomas J. ^{[1
]}

Shi, Min ^{[1
]}

Quinn, Joseph F. ^{[2
]}

Peskind, Elaine R. ^{[3
,4
]}

Craft, Suzanne ^{[3
,5
]}

Ginghina, Carmen ^{[1
]}

Chung, Kathryn A. ^{[2
]}

Kim, Hojoong ^{[5
,6
]}

Galasko, Douglas R. ^{[7
]}

Jankovic, Joseph ^{[8
,9
]}

Zabetian, Cyrus P. ^{[5
,6
]}

Leverenz, James B. ^{[4
,6
]}

Zhang, Jing ^{[1
]}

机构：

[1] Univ Washington, Dept Pathol, Sch Med, Seattle, WA 98104 USA

[2] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97201 USA

[3] Univ Washington, Dept Psychiat & Behav Sci, Sch Med, Seattle, WA 98104 USA

[4] VA Puget Sound Hlth Care Syst, Educ & Clin Ctr, VA NW Network Mental Illness Res, Seattle, WA USA

[5] VA Puget Sound Hlth Care Syst, Ctr Geriatr Res Educ & Clin, Seattle, WA USA

[6] Univ Washington, Dept Neurol, Sch Med, Seattle, WA 98104 USA

[7] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA

[8] Baylor Coll Med, Parkinsons Dis Ctr, Houston, TX 77030 USA

[9] Baylor Coll Med, Dept Neurol, Movement Disorders Clin, Houston, TX 77030 USA

来源：

MOVEMENT DISORDERS | 2010年 / 25卷 / 15期

关键词：

Parkinson's disease; cognitive impairment; CSF biomarkers; A beta(42); tau; CEREBROSPINAL-FLUID; ALZHEIMERS-DISEASE; BIOMARKERS; DEMENTIA; RATIO; BETA;

D O I：

10.1002/mds.23287

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We tested the hypothesis that the CSF biomarker signature associated with Alzheimer's disease (AD) is present in a subset of individuals with Parkinson's disease and Dementia (PD-D) or with PD and Cognitive Impairment, Not Dementia (PD-CIND). We quantified CSF A beta(42), total tau (T-tau), and phospho-tau (P181-tau) using commercially available kits. Samples were from 345 individuals in seven groups (n): Controls <= 50 years (35), Controls > 50 years (115), amnestic Mild Cognitive Impairment (aMCI) (24), AD (49), PD (49), PD-CIND (62), and PD-D (11). We observed expected changes in AD or aMCI compared with age-matched or younger controls. CSF Ab42 was reduced in PD-CIND (P < 0.05) and PD-D (P < 0.01), whereas average CSF T-tau and P181-tau were unchanged or decreased. One-third of PD-CIND and one-half of PD-D patients had the biomarker signature of AD. Abnormal metabolism of Ab42 may be a common feature of PD-CIND and PD-D. (c) 2010 Movement Disorder Society

引用

页码：2682 / 2685

页数：4

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