Antiproliferative Effects of Saponins from the Roots of Platycodon grandiflorum on Cultured Human Tumor Cells

被引：50

作者：

Choi, Yeon Hee ^{[1
,2
]}

Yoo, Dae Seok ^{[1
]}

Cha, Mi-Ran ^{[1
]}

Choi, Chun Whan ^{[1
]}

Kim, Young Sup ^{[1
]}

Choi, Sang-Un ^{[1
]}

Lee, Kang Ro ^{[2
]}

Ryu, Shi Yong ^{[1
]}

机构：

[1] Korea Res Inst Chem Technol, Taejon 305343, South Korea

[2] Sungkyunkwan Univ, Sch Pharm, Suwon 440746, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 11期

关键词：

TRITERPENOID SAPONINS; ACTIVATION; EXTRACT;

D O I：

10.1021/np100496p

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new triterpenoid saponins, platyconic acid B lactone (1), deapio-platyconic acid B lactone (2), and deapio-platycodin D-2 (3), together with 17 known triterpenoid saponins, were isolated from a root extract of Platycodon grandiflorum. The structures of 1-3 were determined on the basis of spectroscopic data interpretation and chemical transformation. Saponins with a platycodigenin or polygalacic acid unit as a sapogenin demonstrated significant inhibitory effects on the proliferation of a small panel of cultured human tumor cells.

引用

页码：1863 / 1867

页数：5

共 29 条

[1] Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-KB activation in RAW 264.7 cells
Ahn, KS
Noh, EJ
Zhao, HL
Jung, SH
Kang, SS
Kim, YS
[J]. LIFE SCIENCES, 2005, 76 (20) : 2315 - 2328
[2] Platycodin D and 2"-o-acetyl-polygalacin D2 isolated from Platycodon grandiflorum protect ischemia/reperfusion injury in the gerbil hippocampus
Choi, Jung Hoon
Yoo, Ki-Yeon
Park, Ok Kyu
Lee, Choong Hyun
Won, Moo-Ho
Hwang, In Koo
Ryu, Shi Yong
Kim, Young Sup
Yi, Jae-Seon
Bae, Young-Soo
Kang, Il-Jun
[J]. BRAIN RESEARCH, 2009, 1279 : 197 - 208
[3] Establishment of doxorubicin-resistant subline derived from HCT15 human colorectal cancer cells
Choi, SU
Kim, NY
Choi, EJ
Kim, KH
Lee, CO
[J]. ARCHIVES OF PHARMACAL RESEARCH, 1996, 19 (05) : 342 - 347
[4] Ameliorating effect of balloon flower saponin on the ethanol-induced memory impairment in mice
Choi, Yeon Hee
Kim, Young Sup
Yeo, Su Jeong
Roh, Seong Hwan
Jeong, Young Chul
Kang, Jong Seong
Ryu, Shi Yong
[J]. PHYTOTHERAPY RESEARCH, 2008, 22 (07) : 973 - 976
[5] Platyconic Acid A, a Genuine Triterpenoid Saponin from the Roots of Platycodon grandiflorum
Choi, Yeon Hee
Yoo, Dae Seok
Choi, Chun Whan
Cha, Mi-Ran
Kim, Young Sup
Lee, Hyun Sun
Lee, Kang Ro
Ryu, Shi Yong
[J]. MOLECULES, 2008, 13 (11) : 2871 - 2879
[6] New A-ring lactone triterpenoid saponins from the roots of Platycodon grandiflorum
Fu, Wen-Wei
Shimizu, Noriko
Takeda, Tadahiro
Dou, De-Qiang
Chen, Baohui
Pei, Yue-Hu
Chen, Ying-Jie
[J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2006, 54 (09) : 1285 - 1287
[7] Studies on the chemical constituents from the roots of Platycodon grandiflorum
Fu, Wen-Wei
Dou, De-Qiang
Shimizu, Noriko
Takeda, Tadahiro
Pei, Yue-Hu
Chen, Ying-Jie
[J]. JOURNAL OF NATURAL MEDICINES, 2006, 60 (01) : 68 - 72
[8] Five new triterpenoid saponins from the roots of Platycodon grandiflorum
Fu, WW
Shimizu, N
Dou, DQ
Takeda, T
Fu, R
Pei, YH
Chen, YJ
[J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2006, 54 (04) : 557 - 560
[9] HARA S, 1987, CHEM PHARM BULL, V35, P501
[10] New triterpenoid saponins from the roots of Platycodon grandiflorum
He, ZD
Qiao, CF
Han, QB
Wang, Y
Ye, WC
Xu, HX
[J]. TETRAHEDRON, 2005, 61 (08) : 2211 - 2215

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