Diagnostic and prognostic prediction using gene expression profiles in high-dimensional microarray data

被引：108

作者：

Simon, R ^{[1
]}

机构：

[1] NCI, Biometr Res Branch, Div Canc Treatment & Diag, Bethesda, MD 20892 USA

来源：

BRITISH JOURNAL OF CANCER | 2003年 / 89卷 / 09期

关键词：

microarray; gene expression profiling; diagnostic classification; prognostic classification;

D O I：

10.1038/sj.bjc.6601326

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

DNA microarrays are a potentially powerful technology for improving diagnostic classification, treatment selection and therapeutics development. There are, however, many potential pitfalls in the use of microarrays that result in false leads and erroneous conclusions. This paper provides a review of the key features to be observed in developing diagnostic and prognostic classification systems based on gene expression profiling and some of the pitfalls to be aware of in reading reports of microarray-based studies.

引用

页码：1599 / 1604

页数：6

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