Basal ganglia and cerebellar inputs to 'AIP'

被引:170
作者
Clower, DM
Dum, RP
Strick, PL
机构
[1] Univ Pittsburgh, Sch Med, Dept Neurobiol, Pittsburgh, PA 15261 USA
[2] Univ Pittsburgh, Sch Med, Dept Neurosurg, Pittsburgh, PA 15261 USA
[3] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15261 USA
[4] Univ Pittsburgh, Sch Med, Pittsburgh Vet Affairs Med Ctr, Pittsburgh, PA 15261 USA
[5] Univ Pittsburgh, Sch Med, Ctr Neural Basis Cognit, Pittsburgh, PA 15261 USA
关键词
basal ganglia; cerebellum; dentate nucleus; posterior parietal cortex; rabies virus; substantia nigra; transneuronal tracing;
D O I
10.1093/cercor/bhh190
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The anterior intraparietal area (AIP) is a subregion of area 7b in posterior parietal cortex. AIP neurons respond to the sight of objects, as well as to the act of grasping them. We used retrograde transneuronal transport of rabies virus to examine subcortical inputs to AIP in the monkey. Virus transport labeled substantial numbers of neurons in the substantia nigra pars reticulata (SNpr), as well as in the dentate nucleus of the cerebellum. The hotspots of labeled neurons in SNpr and in dentate after AIP injections were separate from those created by virus injections into several other parietal or frontal regions. These observations provide the first evidence that a major output nucleus of the basal ganglia, the SNpr, projects to a region of posterior parietal cortex. In addition, our findings provide further support for the concept that posterior parietal cortex is a target of cerebellar output.
引用
收藏
页码:913 / 920
页数:8
相关论文
共 80 条
[1]  
AKKAL D, 2002, SOC NEUR ABSTR, V28
[2]  
AKKAL D, 2001, SOC NEUR ABSTR, V27
[3]   PARALLEL ORGANIZATION OF FUNCTIONALLY SEGREGATED CIRCUITS LINKING BASAL GANGLIA AND CORTEX [J].
ALEXANDER, GE ;
DELONG, MR ;
STRICK, PL .
ANNUAL REVIEW OF NEUROSCIENCE, 1986, 9 :357-381
[4]   Seeing trees but not the forest - Limited perception of large configurations in PD [J].
Barrett, AM ;
Crucian, GP ;
Schwartz, R ;
Nallamshetty, H ;
Heilman, KM .
NEUROLOGY, 2001, 56 (06) :724-729
[5]   A parieto-premotor network for object manipulation: evidence from neuroimaging [J].
Binkofski, F ;
Buccino, G ;
Stephan, KM ;
Rizzolatti, G ;
Seitz, RJ ;
Freund, HJ .
EXPERIMENTAL BRAIN RESEARCH, 1999, 128 (1-2) :210-213
[6]  
BOLLER F, 1984, ARCH NEUROL-CHICAGO, V41, P485, DOI 10.1001/archneur.1984.04050170031011
[7]   FURTHER OBSERVATIONS ON CORTICOFRONTAL CONNECTIONS IN RHESUS-MONKEY [J].
CHAVIS, DA ;
PANDYA, DN .
BRAIN RESEARCH, 1976, 117 (03) :369-386
[8]   The inferior parietal lobule is the target of output from the superior colliculus, hippocampus, and cerebellum [J].
Clower, DM ;
West, RA ;
Lynch, JC ;
Strick, PL .
JOURNAL OF NEUROSCIENCE, 2001, 21 (16) :6283-6291
[9]  
CLOWER DM, 2001, SOC NEUR ABSTR, V27
[10]  
CLOWER DM, 2002, SOC NEUR ABSTR, V28