Basement membrane proteoglycans: From cellar to ceiling

被引:374
作者
Iozzo, RV [1 ]
机构
[1] Thomas Jefferson Univ, Kimmel Canc Ctr, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA
[2] Thomas Jefferson Univ, Kimmel Canc Ctr, Cellular Biol & Signalling Program, Philadelphia, PA 19107 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/nrm1702
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The biology of basement membrane proteoglycans extends far beyond the original notion of anionic filters. These complex molecules have dual roles as structural constituents of basement membranes and functional regulators of several growth-factor signalling pathways. As such, they are involved in angiogenesis and, consequently, in tumour progression and their partial or total absence causes several congenital defects that affect the musculoskeletal, cardiovascular and nervous systems. New findings indicate a potential functional coupling between the intricate make-up of basement membrane proteoglycans and their ability to control important biological processes.
引用
收藏
页码:646 / 656
页数:11
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