Isolation and NMR characterization of rosacelose, a novel sulfated polysaccharide from the sponge Mixylla rosacea

被引：26

作者：

Cimino, P ^{[1
]}

Bifulco, G ^{[1
]}

Casapullo, A ^{[1
]}

Bruno, I ^{[1
]}

Gomez-Paloma, L ^{[1
]}

Riccio, R ^{[1
]}

机构：

[1] Univ Salerno, Dipartimento Sci Farmaceut, I-84084 Fisciano, SA, Italy

来源：

CARBOHYDRATE RESEARCH | 2001年 / 334卷 / 01期

关键词：

Mixylla rosacea; rosacelose; sulfated polysaccharide; 2D-NMR; HIV; fucoidan; glucan; marine sponge;

D O I：

10.1016/S0008-6215(01)00141-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rosacelose, a new anti-HIV polysaccharide composed of glucose and fucose sulfate, has been isolated from an aqueous extract of the marine sponge Mixylla rosacea. Extensive use of H-1 and C-13 multidimensional NMR spectroscopy, combined with chemical analysis were used to establish a linear polysaccharide structure composed mainly of 4,6-disulfated 3-O-glycosylated alpha -D-glucopyranosyl and 2,4-disulfated 3-O-glycosylated alpha -L-fucopyranosyl residues (in a 3:1 molar ratio). (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：39 / 47

页数：9

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