Senescence marker protein 30 (SMP30)/regucalcin (RGN) expression decreases with aging, acute liver injuries and tumors in zebrafish

被引：29

作者：

Fujisawa, Koichi ^{[2
]}

Terai, Shuji ^{[1
]}

Hirose, Yoshikazu ^{[1
]}

Takami, Taro ^{[3
]}

Yamamoto, Naoki ^{[1
]}

Sakaida, Isao ^{[1
,2
]}

机构：

[1] Yamaguchi Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Ube, Yamaguchi 7558505, Japan

[2] Yamaguchi Univ, Sch Med, Ctr Reparat Med, Ube, Yamaguchi 7558505, Japan

[3] Yamaguchi Univ, Div Lab, Ube, Yamaguchi 7558505, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2011年 / 414卷 / 02期

基金：

日本学术振兴会;

关键词：

Zebrafish; Liver tumors; Aging; Senescence marker protein 30 (SMP30); Regucalcin; HEPATOMA H4-II-E CELLS; REGUCALCIN MESSENGER-RNA; RAT-LIVER; GENE-EXPRESSION; MODEL; OVEREXPRESSION; PROLIFERATION; REGENERATION; CARCINOMA; GROWTH;

D O I：

10.1016/j.bbrc.2011.09.067

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Senescence marker protein 30 (SMP30)/regucalcin (RGN) is known to be related to aging, hepatocyte proliferation and tumorigenesis. However, expression and function of non-mammalian SMP30/RGN is poorly understood. We found that zebrafish SMP30/RGN mRNA expression decreases with aging, partial hepatectomy and thioacetamide-induced acute liver injury. SMP30/RGN expression was also greatly decreased in a zebrafish liver cell line. In addition, we induced liver tumors in adult zebrafish by administering diethylnitrosamine. Decreased expression was observed in foci, hepatocellular carcinomas, cholangiocellular carcinomas and mixed tumors as compared to the surrounding area. We thus showed the importance of SMP30/RGN in liver proliferation and tumorigenesis. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：331 / 336

页数：6

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