Different cytokines modulate ubiquitin gene expression in rat skeletal muscle

被引:89
作者
Llovera, M
Carbó, N
López-Soriano, J
García-Martínez, C
Busquets, S
Alvarez, B
Agell, N
Costelli, P
López-Soriano, FJ
Celada, A
Argilés, JM
机构
[1] Univ Barcelona, Unitat Bioquim & Biol Mol B, Dept Bioquim & Biol Mol, Fac Biol, Barcelona 08071, Spain
[2] Univ Barcelona, Fac Med, Dept Cellular Biol, Barcelona 7, Spain
[3] Univ Turin, Dipartimento Med & Oncol Sperimentale, Turin, Italy
[4] Univ Barcelona, Fac Biol, Dept Fisiol, Barcelona, Spain
关键词
TNF-alpha; IL-1; IL-6; IFN-gamma; LIF; cancer cachexia; muscle waste;
D O I
10.1016/S0304-3835(98)00216-X
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Intravenous administration of different cytokines caused important changes in the expression of ubiquitin genes in skeletal muscle. Tumour necrosis factor-alpha caused a 2.2- and 1.9-fold increase in the expression of the 2.4 and 1.2 kb transcripts, respectively. Administration of interferon-gamma also caused a 2.2- and 1.8-fold increase in the 2.4 and 1.2 kb transcripts, respectively. While administration of leukaemia inhibitory factor and interleukin-6 resulted in no changes in ubiquitin gene expression, interleukin-l administration also caused an increase in both ubiquitin gene transcripts (2.8- and 1.9-fold for the 2.4 and 1.2 kb transcripts, respectively). The results suggest that some of the cytokine effects on the ubiquitin system gene expression could be related to the enhanced skeletal muscle proteolysis found during cancer cachexia and other pathological states. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:83 / 87
页数:5
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