Endometrial biopsy during outpatient hysteroscopy: evaluation and comparison of two devices

Objective: Association of office hysteroscopy with outpatient endometrial biopsy is interesting to evaluate correctly endometrium. Purpose of this study was to evaluate and compare two endometrial biopsy devices during outpatient hysteroscopy, based on effectiveness and tolerance of the procedure. Study Design: A single blind, randomised prospective study. Results: 200 patients were randomised into two groups following outpatient hysteroscopy: 100 were biopsied with Vacurette and 100 biopsed with Pipelle. Pipelle was less painful compared to Vacurette (1.1 + 0.2 versus 1.6 + 0.3; P < 0.001), no matter hormonal status (1 + 0.3 versus 2 + 0.6; P < 0.001 in premenopausal subgroup and 1 + 0.3 versus 1.4 + 0.3; P < 0.001 in postmenopausal subgroup). Vacurette was more effective than Pipelle (64/100 versus 48/100; P = 0.02), in case of normal or hypertrophic endometrium (56/72 (77%) versus 40/65 (61%); P = 0.04) but not in case of atrophic endometrium (8/28 (29%) versus 8/35 (23%); P = 0.6). Among the 112 patients with adequate sample, histologic results were normal, except for three cases of endometrial hyperplasia. Among the 88 patients with inadequate sample, 47 (53%) presented an atrophic endometrial aspect at hysteroscopy, whereas 41 (47%) were considered as normal. Conclusions: Vacurette was snore effective though more painful than Pipelle. Both instruments were, however, well tolerated. Both instruments were not very effective in case of atrophic endometrium. Outpatient hysteroscopy combined with endometrial biopsy may help avoid further investigations. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.