Synthesis of Novel Derivatives of Esculentoside A and Its Aglycone Phytolaccagenin, and Evaluation of Their Haemolytic Activity and Inhibition of Lipopolysaccharide-Induced Nitric Oxide Production

被引：15

作者：

Gong, Wei ^{[1
]}

Jiang, Zhihui ^{[1
]}

Sun, Peng ^{[1
]}

Li, Ling ^{[1
]}

Jin, Yongsheng ^{[1
]}

Shao, Lucheng ^{[1
]}

Zhang, Wen ^{[1
]}

Liu, Baoshu ^{[1
]}

Zhang, Hongwei ^{[2
]}

Tang, Hua ^{[1
]}

Chen, Yufeng ^{[3
]}

Yi, Yanghua ^{[1
]}

Zhang, Dazhi ^{[1
]}

机构：

[1] Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China

[2] Eighth Hosp PLA, Dept Pharm, Xigaze 857000, Peoples R China

[3] Shenyang N Hosp, Dept Pharm, Shenyang 110016, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2011年 / 8卷 / 10期

关键词：

INTERLEUKIN-1; CYTOTOXICITY; MACROPHAGES;

D O I：

10.1002/cbdv.201000339

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

A series of 46 compounds derived from esculentoside A and its aglycone were synthesized and characterized. The effect of these compounds on lipopolysaccharide (LPS)-induced NO production, haemolytic activity, and cell viability was evaluated. Structure-activity relationship was established by comparing the derivatives of esculentoside A with its aglycone derivatives. Both the aglycone and its derivatives showed higher inhibitory effects on LPS-induced NO production, and lower haemolytic activities than esculentoside A and its derivatives.

引用

页码：1833 / 1852

页数：20

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