The common D302H variant of CASP8 is associated with risk of glioma

被引：35

作者：

Bethke, Lara ^{[1
]}

Sullivan, Kate ^{[1
]}

Webb, Emily ^{[1
]}

Murray, Anne ^{[1
]}

Schoemaker, Minouk ^{[2
]}

Auvinen, Anssi ^{[3
,4
]}

Kiuru, Anne ^{[3
]}

Salminen, Tiina ^{[3
,4
]}

Johansen, Christoffer ^{[5
]}

Christensen, Helle Collatz ^{[5
]}

Muir, Kenneth ^{[6
]}

McKinney, Patricia ^{[7
]}

Hepworth, Sarah ^{[7
]}

Dimitropoulou, Polyxeni ^{[6
]}

Lophatananon, Artitaya ^{[6
]}

Feychting, Maria ^{[8
]}

Lonn, Stefan ^{[9
]}

Ahlbom, Anders ^{[8
]}

Malmer, Beatrice ^{[10
]}

Henriksson, Roger ^{[10
]}

Swerdlow, Anthony ^{[2
]}

Houlston, Richard ^{[1
]}

机构：

[1] Inst Canc Res, Sect Canc Genet, Sutton SM2 5NG, Surrey, England

[2] Inst Canc Res, Epidemiol Sect, Sutton SM2 5NG, Surrey, England

[3] Univ Tampere, Tampere Sch Publ Hlth, Dept Epidemiol, FIN-33101 Tampere, Finland

[4] Radiat & Nucl Safety Author, Dept Res & Environm Surveillance, Helsinki, Finland

[5] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[6] Univ Nottingham, Sch Med, Queens Med Ctr, Div Epidemiol & Publ Hlth, Nottingham, England

[7] Ctr Biostat & Epidemiol, Leeds, W Yorkshire, England

[8] Karolinska Inst, Inst Environm Med, Div Epidemiol, S-10401 Stockholm, Sweden

[9] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[10] Umea Univ, Dept Radiat Sci, Umea, Sweden

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2008年 / 17卷 / 04期

关键词：

D O I：

10.1158/1055-9965.EPI-07-2807

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Caspase 8 (CASP8) is a key regulator of apoptosis or programmed cell death, and, hence, a defense against cancer. We tested the hypothesis that the CASPS polymorphism D302H influences risk of glioma through analysis of five series of glioma case patients and controls (n = 1,005 and 1,011, respectively). Carrier status for the rare allele of D302H was associated with a 1.37-fold increased risk (95% confidence interval, 1.10-1.70; P = 0.004). The association of CASP8 D302H with glioma risk indicates the importance of inherited variation in the apoptosis pathway in susceptibility to this form of primary brain tumor.

引用

页码：987 / 989

页数：3

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