Aqueous Fenugreek Seed Extract Ameliorates Adriamycin-Induced Cytotoxicity and Testicular Alterations in Albino Rats

被引：15

作者：

Sakr, Saber A. ^{[1
]}

El-shenawy, Salama M. ^{[2
]}

Al-Shabka, Ahmed M. ^{[1
]}

机构：

[1] Menoufia Univ, Fac Sci, Dept Zool, Shibin Al Kawm, Egypt

[2] Menoufia Univ, Teaching Hosp, Dept Lab, Shibin Al Kawm 32511, Egypt

来源：

REPRODUCTIVE SCIENCES | 2012年 / 19卷 / 01期

关键词：

adriamycin; fenugreek; chromosomal aberrations; testis; antioxidants; INDUCED OXIDATIVE STRESS; FOENUM-GRAECUM SEEDS; BONE-MARROW-CELLS; DIABETIC-RATS; LIPID-PEROXIDATION; PROTECTIVE ROLE; DNA-DAMAGE; IN-VITRO; DOXORUBICIN; ANTIOXIDANT;

D O I：

10.1177/1933719111413301

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The present work studied the effect of fenugreek seed extracts on cytotoxicity and testicular damage induced by adriamycin (ADR) in albino rats. Administrating animals with ADR caused significant increase in the percentage of chromosomal aberrations, decreased the mitotic index, and induced DNA damage in bone marrow. Testes of ADR-treated rats showed many histopathological alterations and the number of sperm head abnormalities increased. Moreover, the concentration of malondialdehyde (MDA) increased and the activity of catalase (CAT) and superoxide dismutase (SOD) decreased in the testis. Treating animals with ADR and aqueous seed extracts of fenugreek led to an improvement in the cytogenetic effect and testicular alterations induced by ADR. Lipid peroxidation was reduced and the activities of CAT and SOD were increased. In conclusion, the results indicated that fenugreek seeds ameliorated the cytotoxicity and testicular alterations induced by ADR in albino rats and this may be mediated by its potent antioxidant effects.

引用

页码：70 / 80

页数：11

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