Nerve growth factor mRNA and protein levels measured in the same tissue from normal and Alzheimer's disease parietal cortex

被引：104

作者：

Fahnestock, M ^{[1
]}

Scott, SA ^{[1
]}

Jette, N ^{[1
]}

Weingartner, JA ^{[1
]}

Crutcher, KA ^{[1
]}

机构：

[1] UNIV CINCINNATI,MED CTR,DEPT NEUROSURG,CINCINNATI,OH 45267

来源：

MOLECULAR BRAIN RESEARCH | 1996年 / 42卷 / 01期

关键词：

nerve growth factor; neurotrophic factor; basal forebrain; retrograde transport; neurodegeneration; dot blots; ELISA;

D O I：

10.1016/S0169-328X(96)00193-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nerve growth factor (NGF) mRNA and protein levels were determined in parietal cortex samples from both normal and Alzheimer's disease (AD) patients. NGF protein levels were slightly elevated in AD patients compared to controls, but NGF mRNA levels were unchanged in the same tissue samples. Thus, small but reproducible increases in NGF protein reported in AD cortex do not result from increases in NGF mRNA.

引用

页码：175 / 178

页数：4

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