Sex-related suppression of reflex jaw muscle activity by peripheral morphine but not GABA

被引：23

作者：

Cai, BBY ^{[1
]}

Cairns, BE ^{[1
]}

Sessle, BJ ^{[1
]}

Hu, JW ^{[1
]}

机构：

[1] Univ Toronto, Fac Dent, Toronto, ON M5G 1G6, Canada

来源：

NEUROREPORT | 2001年 / 12卷 / 16期

关键词：

GABA; glutamate; jaw muscles; morphine; naloxone; rat; temporomandibular joint;

D O I：

10.1097/00001756-200111160-00016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study examined the effect of peripherally applied morphine and GABA on jaw muscle electromyographic activity reflexly evoked by co-Injection of glutamate into the temporomandibular joint (TMJ) of lightly anesthetized Sprague-Dawley rats of both sexes. In male but not female rats, morphine significantly suppressed glutamate-evoked jaw muscle activity in a dose-dependent and naloxone-reversible manner. The median suppressive dose (+/-s.e,) for male rats was 12.7 +/-3.1 mug (digastric muscle) and 12.6 +/-1.3 mug (masseter muscle). GABA (5 mu mol) significantly reduced glutamate-evoked muscle activity in both sexes. These data suggest that female rats are considerably less. sensitive than male, rats to the suppressive effects of peripherally applied morphine, but both sexes are equally affected by peripherally applied GABA. (C) 2001 Lippincott Williams & Wilkins.

引用

页码：3457 / 3460

页数：4

共 25 条

[1] Morphine application to peripheral tissues modulates nociceptive jaw reflex [J].