Antioxidant effect of flavonoids

被引:79
作者
Catapano, AL [1 ]
机构
[1] UNIV MILAN,CTR STUDIO PREVENZ & TERAPIA VASCULOPATIE ATEROSC,MILAN,ITALY
关键词
D O I
10.1177/000331979704800107
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Our body generates hydroxyl radicals under a number of conditions. This radical is very unstable and, therefore, very reactive. After attack of radicals on membranes and lipoproteins, lipid peroxidation starts, and may lead to the development of vascular lesions. The human body has developed antioxidant defenses to protect against free radicals such as superoxide dismutases, glutathione peroxidases, plasma iron binding proteins, or a tocopherol. Oxidized LDL are believed to play a key role in vascular damage and can modulate several endothelial properties including NO production and expression of adhesion molecules. Antioxidants, such as flavonoids, inhibit ''in vitro'' oxidation of LDL and their cytotoxicity; in humans consumption of flavonoids appears to be related to a reduction of the risk of cardiovascular diseases. The biochemical mechanisms responsible for this effect remain to be addressed.
引用
收藏
页码:39 / 44
页数:6
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