Estimation of pore diameter for intraparticle fluid flow in bidisperse porous chromatographic particles

A quantitative method is developed and presented for estimating the mean pore diameter, d(pore), that could allow intraparticle fluid flow in the macroporous region of adsorbent particles with a bidisperse porous structure packed in a column. The method is used to estimate the value of d(pore) that is required to obtain specified values of the fraction, F, of the column superficial fluid velocity that is flowing through the macroporous region of the adsorbent particles and the value of d(pore) that is required to obtain specified values of the intraparticle Peclet number, Pe(intra).